Robert P. Machold

This study shows dendritic inhibition terminates plateau potentials in CA1 pyramidal neurons through specific interneuron subtypes and voltage-gated calcium channels.

The paper uses a novel genetic labeling approach to show variation in Cajal-Retzius cell density and persistence across different cortical areas in mice.

The paper identifies four distinct VIP interneuron populations in the neocortex with unique connectivity and responses to neuromodulation, showing specialized roles in cortical circuit regulation.

The paper identifies functional subtypes of hippocampal somatostatin-expressing interneurons using transcriptomic features and transgenic mouse models.

The paper identifies a fourth major group of cortical inhibitory neurons, Id2 GABAergic interneurons, characterized by neurogliaform cells and distinct electrophysiological properties.

The paper investigates inhibitory plasticity in mouse auditory cortex, finding that SST+ interneuron inputs show the most potentiation and contribute to decision accuracy under noise.

The paper shows that bottom-up thalamic inputs are essential for establishing top-down connectivity to layer 1 neurogliaform cells in the visual cortex during early development.

The paper labels intrinsic hand and foot motor neurons using an Atoh1 CRE knock-in mouse line, showing they have a unique developmental history and can be targeted for functional studies.

The paper shows that cellular birthdate determines laminar and regional specificity of cholinergic projections in the forebrain.

The paper profiles interneurons in primates and rodents to identify evolutionary innovations in brain cell types and their molecular features.

The paper uses single-cell RNA-seq to study the development of cortical interneurons, identifying key transcription factors and cell states involved in their diversification.

This study shows that Drosophila Insomniac and its mammalian orthologs are functionally conserved in sleep regulation and synaptic function through an evolutionarily conserved ubiquitination pathway.