Gord Fishell

The functional diversification of somatosensory neuron repertoires across Mammalia

The paper shows that somatosensory neuron repertoires in mammals diversify through changes to conserved neuron types, enabling adaptation to different habitats and body forms.

Early-life medial pulvinar disruption drives schizophrenia-relevant prefrontal inhibitory and cognitive deficits in primates

This study shows that early-life disruption of the medial pulvinar in marmosets leads to adult prefrontal inhibitory and cognitive deficits relevant to schizophrenia.

SNNs Are Not Transformers (Yet): The Architectural Problems for SNNs in Modeling Long-Range Dependencies

This paper analyzes the limitations of spiking neural networks (SNNs) in modeling long-range dependencies, showing their quadratic sample complexity compared to Transformers and RNNs.

Cognitive function depends upon Satb2 gene dosage in cortical projection neurons

This study shows that reduced Satb2 gene dosage in cortical projection neurons leads to chromatin and circuit defects, causing cognitive and sensory impairments in a mouse model of SATB2-associated syndrome.

Developmental dysregulation of chandelier cell excitability in a mouse model of Dravet Syndrome

This study examines chandelier cell excitability in Dravet Syndrome mice, finding impaired excitability in juvenile and adult stages, distinct from basket cells.

Cellular and circuit mechanisms underlying binocular vision

This study identifies cellular and circuit mechanisms in mouse V1 that process binocular visual information, showing distinct roles for callosal projections and neuronal excitability.

LARIS enables accurate and efficient ligand and receptor interaction analysis in spatial transcriptomics

LARIS identifies cell type-specific and spatially restricted ligand-receptor interactions in spatial transcriptomics data with high accuracy and scalability.

Biologically Realistic Computational Primitives of Neocortex Implemented on Neuromorphic Hardware Improve Vision Transformer Performance

The paper implements biologically realistic neocortical circuit motifs on neuromorphic hardware to improve Vision Transformer performance in digit classification.

Discrete interneuron subsets participate in GluN1/GluN3A excitatory glycine receptor (eGlyR)-mediated regulation of hippocampal network activity throughout development and evolution.

The paper shows that eGlyRs in hippocampal interneurons regulate network activity through developmental and evolutionary conserved mechanisms.

A novel, evolutionarily conserved inhibitory circuit selectively regulates dentate gyrus mossy cell function.

The paper identifies a novel inhibitory interneuron subtype in the dentate gyrus that selectively regulates mossy cell function and shows this pattern is evolutionarily conserved across species.

Reciprocal interaction between cortical SST and PV interneurons in regulating top-down retinothalamic refinement

This study shows that cortical SST and PV interneurons have opposing roles in regulating retinogeniculate connectivity during thalamic refinement.

An enhancer-AAV toolbox to target and manipulate distinct interneuron subtypes

The paper identifies enhancer-AAV tools for specific neuronal subtypes and validates them across species.

An Anatomical and Physiological Basis for Flexible Coincidence Detection in the Auditory System

The paper explains how octopus cells in the auditory brainstem detect coincident inputs on both millisecond and submillisecond time scales, enhancing the ability to process complex sounds.

Pyramidal neurons proportionately alter the identity and survival of specific cortical interneuron subtypes

The paper shows pyramidal neurons influence the survival and identity of specific interneuron subtypes through non-synaptic mechanisms.

Metabotropic signaling within somatostatin interneurons regulates thalamocortical inputs during development

The paper shows that metabotropic signaling in somatostatin interneurons eliminates transient thalamocortical inputs during development, affecting adult exploratory behavior.

Neurogliaform Cells Exhibit Laminar-specific Responses in the Visual Cortex and Modulate Behavioral State-dependent Cortical Activity

This study investigates neurogliaform cells in the visual cortex, showing their activity correlates with locomotion and their functional role is influenced by laminar position and connectivity.

Disruption of Cholinergic Retinal Waves Alters Visual Cortex Development and Function

This study disrupts cholinergic retinal waves in mice and shows impaired visual cortex development and function, including altered retinotopy and sensory processing.

Divergent opioid-mediated suppression of inhibition between hippocampus and neocortex across species and development

The paper shows that opioids suppress inhibition in hippocampal PV-INs but not neocortex across species and development, highlighting conserved and divergent roles in neural circuits.

Nova proteins direct synaptic integration of somatostatin interneurons through activity-dependent alternative splicing

This study shows that Nova proteins, through activity-dependent alternative splicing, are essential for the maturation and connectivity of somatostatin interneurons.

Cortical somatostatin interneuron subtypes form cell-type specific circuits

The paper identifies cell-type specific circuits formed by subtypes of somatostatin interneurons in the cortex through genetic targeting and connectivity analysis.

The organization and developmental establishment ofcortical interneuron presynaptic circuits

The paper maps presynaptic inputs to PV and SST cortical interneurons across cortical areas, revealing region-specific developmental patterns and differential vulnerability to neurodevelopmental disorders.

Bottom-up inputs are required for the establishment of top-down connectivity onto cortical layer 1 neurogliaform cells

The paper shows that bottom-up thalamic inputs are essential for establishing top-down connectivity to layer 1 neurogliaform cells in the visual cortex during early development.

A transient postnatal quiescent period precedes emergence of mature cortical dynamics

The paper identifies a transient quiescent period in early postnatal development that precedes the emergence of mature cortical dynamics in mice and humans.

Motor neurons involved in fine motor control are labeled by tracing Atoh1-lineage neurons in the spinal cord

The paper labels intrinsic hand and foot motor neurons using an Atoh1 CRE knock-in mouse line, showing they have a unique developmental history and can be targeted for functional studies.

Monitoring phagocytic uptake of amyloid β into glial cell lysosomes in real time

This study develops a fluorescent Aβ analogue to monitor glial cell phagocytosis of amyloid β in real time, showing microglia uptake exceeds astrocytes.

Cellular birthdate predicts laminar and regional cholinergic projection topography in the forebrain

The paper shows that cellular birthdate determines laminar and regional specificity of cholinergic projections in the forebrain.

Hippocampal inputs engage CCK+ interneurons to mediate endocannabinoid-modulated feed-forward inhibition in the prefrontal cortex

This study investigates how ventral hippocampus inputs engage inhibitory interneurons in the prefrontal cortex, revealing specific roles for CCK+ interneurons and endocannabinoid modulation in feed-forward inhibition.

Innovations in Primate Interneuron Repertoire

The paper profiles interneurons in primates and rodents to identify evolutionary innovations in brain cell types and their molecular features.

Viral manipulation of functionally distinct neurons from mice to humans

The paper identifies enhancers for targeting specific neuronal subtypes across species and demonstrates their utility in circuit manipulation.

Characterizing the epigenetic landscape of cellular populations from bulk and single-cell ATAC-seq information.

The paper introduces ChromA, a Bayesian method for analyzing ATAC-seq data to annotate chromatin accessibility, improving cell type identification and correcting biases in single-cell data.