Author

Amy J. Heidersbach

GenentechORCID 0000-0002-5601-2073Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:CRISPR screen· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Benjamin HaleyiD· 2 shared Alejandra MartíneziD· 1 shared Andrew H. NgiD· 1 shared Andrew J. KuehiD· 1 shared Anna SalvioniiD· 1 shared Azalia Sandles· 1 shared Bastien CabarrouiD· 1 shared Carlos Gomez‐RocaiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCancer Biology

Benjamin HaleyORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A novel, high-density CRISPR activation platform for mapping cancer dependencies and resistance pathways ex vivo and in vivo

Sarah T. Diepstraten, Yexuan Deng, Margaret A. Potts, Amy J. Heidersbach, Christina Koenig, Kristel M. Dorighi, Lin Tai, Andrew J. Kueh, Lauren Whelan, Catherine W.T. Chang, Felix Brown, Gemma L. Kelly, Jean‐Philippe Fortin, Benjamin Haley, John E. La Marca, Marco J. Herold

This paper introduces Partita, a high-density CRISPRa platform for comprehensive gene activation studies, demonstrating its utility in identifying cancer dependencies and resistance pathways in vitro and in vivo.

Science Advances · Sep 18, 2026Peer-reviewedCancer Biology

Systemic neoantigen-specific T cells reveal central determinants of PD-(L)1 blockade efficacy

Célia Ramade, Noémie Thébault, Clara‐Maria Scarlata, Daniel Oreper, Françoise Lauzéral-Vizcaïno, Suchit Jhunjhunwala, Bastien Cabarrou, Milena Hornburg, Caroline Fournier, Anna Salvioni, Marie Michelas, Victor Sarradin, Giulia Costanza Leonardi, Virginie Féliu, Myriam Maixent, , Maha Ayyoub

The paper identifies coordinated neoantigen-specific CD8 T cell responses as key predictors of PD-(L)1 therapy efficacy in non-small cell lung cancer patients.

bioRxiv · Mar 12, 2026 · PreprintCancer Biology

Chemically-inducible CRISPR/Cas9 circuits for ultra-high dynamic range gene perturbation

Rajini Srinivasan, Tao Sun, Azalia Sandles, Diana H. Wu, Liang Wang, Hetal Patel, Ryan Pabalate, Maram Bader, Amy J. Heidersbach, Clark Ho, Shiqi Xie, Andrew H. Ng, Benjamin Haley

This paper develops inducible CRISPR/Cas9 systems with improved dynamic range and reduced off-target effects for precise gene perturbation.

Nature Communications · Dec 12, 2025Peer-reviewedMolecular Biology