Author

Chia‐Ju Hsieh

University of PennsylvaniaORCID 0000-0002-2833-7727Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Research Focus:drug response / drug discovery· 1 Assay:imaging· 1 Organism:rat· 1

Frequent Co-Authors

Robert H. MachiD· 3 shared Catherine HouiD· 2 shared Hsiaoju S. LeeiD· 2 shared Ji Youn LeeiD· 2 shared Shihong LiiD· 2 shared Alexander M. Th. SchmitziD· 1 shared Anthony J. YoungiD· 1 shared Chi-Chang WengiD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersNeuroscience

Robert H. MachORCID

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3 papers

Recent·Most cited

A Small-molecule Antagonist Radiotracer for Positron Emission Tomography Imaging of the Mu Opioid Receptor.

Konstantinos Plakas, Chia‐Ju Hsieh, Dinahlee Saturnino Guarino, Catherine Hou, Wai‐Kit Chia, Anthony J. Young, Alexander M. Th. Schmitz, Yi-Pei Ho, Chi-Chang Weng, Hsiaoju S. Lee, Shihong Li, Thomas J. A. Graham, Robert H. Mach

This paper designs and characterizes non-agonist ligands for the mu opioid receptor, identifies a radiotracer [11C]1A for PET imaging, and demonstrates its brain uptake and receptor specificity in rhesus macaques.

bioRxiv · Oct 12, 2024 · PreprintNeuroscience

ROStrace detects oxidative stress in vivo and predicts progression of Alzheimer's disease pathology in APP/PS1 mice.

Chia‐Ju Hsieh, Catherine Hou, Yi Zhu, Ji Youn Lee, Neha Kohli, Evan P. Gallagher, Kuiying Xu, Hsiaoju S. Lee, Shihong Li, Meagan J. McManus, Robert H. Mach

This paper demonstrates that [18F]ROStrace PET imaging detects oxidative stress in APP/PS1 mice and correlates with amyloid burden, predicting Alzheimer's disease progression.

EJNMMI Research · Jul 27, 2022Peer-reviewedNeuroscience

Poly(ADP-ribose) induces α-synuclein aggregation in neuronal-like cells andinteracts with phosphorylated α-synuclein in post mortem PD samples

Laura N. Puentes, Zsofia Lengyel‐Zhand, Ji Youn Lee, Chia‐Ju Hsieh, Mark E. Schneider, Kimberly J. Edwards, Kelvin C. Luk, Virginia M.‐Y. Lee, John Q. Trojanowski, Robert H. Mach

This study shows that PAR promotes α-synuclein aggregation and interacts with phosphorylated α-synuclein in Parkinson's disease samples.

bioRxiv · Apr 8, 2020 · PreprintNeuroscience