Precision Targeting of Heparan Sulfate Proteoglycans Broadly Dysregulates Survival Signaling and Metabolic Adaptation in Pancreatic Cancer
Nancy D. Ebelt, Suvithanandhini Loganathan, Lara C. Avsharian…·Edwin Ramos Manuel
This study shows that targeting heparan sulfate proteoglycans in pancreatic cancer with bacterial heparinase III reduces survival signaling and metabolic adaptation, potentially improving therapy efficacy.