Koenraad Van Doorslaer

Human Papillomavirus Infection Blunts STING Signaling and Alters Downstream Response

This study shows HPV infection increases cGAMP but reduces STING and IRF3 activation, dampening antiviral responses while increasing epithelial proliferation genes.

Complex HPV-human DNA structures revealed by large-scale DNA analyses in an HPV-cancer derived cell line

The paper uses genomic tools to analyze HPV-human DNA integration structures in a cancer cell line, revealing complex intrachromosomal and extrachromosomal architectures.

Cell-based high-content approach for SARS-CoV-2 neutralization identifies unique monoclonal antibodies and PI3K pathway inhibitors.

This study uses high-throughput screens in human cells with authentic SARS-CoV-2 virus to identify neutralizing monoclonal antibodies and kinase inhibitors with minimal host toxicity.

PRMT1 Modulates Alternative Splicing to Enhance HPV18 mRNA Stability and Promote the Establishment of Infection

This study identifies PRMT1 as a critical factor in HPV18 infection by modulating alternative splicing and mRNA stability, promoting persistent infection in primary human cervical cells.

PuMA: a papillomavirus genome annotation tool

PuMA annotates papillomavirus genomes with 98% accuracy and was used to annotate 1424 features from 168 new isolates.