Florent Ginhoux

This study shows that CSF-1 signaling is essential for cerebellar microglia identity and function, and its disruption causes motor and social behavior defects.

This study shows that prenatal inflammation and macrophage depletion affect PV interneuron wiring in two distinct ways during development and adulthood, leading to altered inhibitory circuit function.

The paper develops a rule-based data-informed approach to create a consensus map of the human mononuclear phagocyte cell space using computational integration and single-cell RNA-sequencing.

The paper investigates how microbiota affects myelination and white matter plasticity in a Huntington disease mouse model, finding altered myelin thickness and oligodendrocyte numbers in germ-free conditions.

The paper evaluates UMAP as an alternative to t-SNE for single-cell data, finding it faster, more consistent, and better at preserving cluster organization and continuums.

This study identifies nine distinct microglial states in mice across lifespan and after injury using single-cell RNA sequencing, revealing persistent and age-related changes.

This study investigates how IL4 signalling and NCOR2 regulate the reprogramming of human monocytes into dendritic cells and macrophages, revealing distinct transcriptional and functional profiles based on cytokine exposure timing.