Suppression of T cell function by phosphoethanolamine, a metabolite enriched in tumor interstitial fluid
Yupeng Wang, Drew N. Wilfahrt, Patrick B. Jonker, Konstantinos Lontos, Chufan Cai, Benjamin Cameron, Bingxian Xie, Ronal M. Peralta, Emerson R Schoedel, William G. Gunn, Roya AminiTabrizi, Hardik Shah, Dayana B. Rivadeneira, Alexander Muir, Greg M. Delgoffe
This study identifies phosphoethanolamine as a key metabolite in tumor interstitial fluid that suppresses T cell function by inhibiting TCR signaling.
Nature Cell Biology · Apr 21, 2025Peer-reviewedImmunology