Patrick B. Jonker

Tumor nutrient stress gives rise to a drug tolerant cell state in pancreatic cancer

This study shows that pancreatic cancer cells in a nutrient-stressed tumor microenvironment develop drug tolerance, and identifies BCL-XL inhibition as a potential therapeutic strategy.

Suppression of T cell function by phosphoethanolamine, a metabolite enriched in tumor interstitial fluid

This study identifies phosphoethanolamine as a key metabolite in tumor interstitial fluid that suppresses T cell function by inhibiting TCR signaling.

Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis

The paper shows that arginine restriction in the tumor microenvironment limits lipid synthesis in pancreatic cancers, making them susceptible to polyunsaturated fatty acids via ferroptosis.