Author

Bingxian Xie

University of PittsburghORCID 0000-0001-9816-2670Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Greg M. DelgoffeiD· 2 shared Alexander MuiriD· 1 shared An‐Chi WeiiD· 1 shared Benjamin Cameron· 1 shared Brian P O'RourkeiD· 1 shared Chufan CaiiD· 1 shared David A. KassiD· 1 shared Dayana B. RivadeneiraiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersImmunology

Greg M. DelgoffeORCID

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3 papers

Recent·Most cited

ImmunologyNature Cell BiologyPeer-reviewedApr 21, 2025

Suppression of T cell function by phosphoethanolamine, a metabolite enriched in tumor interstitial fluid

Yupeng Wang, Drew N. Wilfahrt, Patrick B. Jonker…·Greg M. Delgoffe

This study identifies phosphoethanolamine as a key metabolite in tumor interstitial fluid that suppresses T cell function by inhibiting TCR signaling.

27 citationstop 1%

humanbulk RNA-seq

𝕏 PostBluesky

ImmunologybioRxivPreprintOct 22, 2024

Engineered protein destabilization reverses intrinsic immune evasion for candidate vaccine pan-strain KSHV and SARS-CoV-2 antigens

Li Wan, Bingxian Xie, Masahiro Shuda…·Patrick S. Moore

The paper shows engineered destabilization of viral proteins enhances T cell recognition, improving vaccine efficacy against KSHV and SARS-CoV-2.

2 citations

mouseproteomics

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Molecular BiologybioRxivPreprintJan 19, 2021

Myocardial BDNF regulates cardiac bioenergetics through the transcription factor Yin Yang 1

Xue Yang, Manling Zhang, Bingxian Xie…·Ning Feng

This study shows that myocardial BDNF signaling via YY1 regulates cardiac bioenergetics and mitochondrial function during stress.

DOI 10.1101/2021.01.19.427213

mousebulk RNA-seq

𝕏 PostBluesky