Author

N. Maltseva

Argonne National LaboratoryORCID 0000-0002-2871-465XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:virus· 2 Research Focus:drug response / drug discovery· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

A. JoachimiakiD· 3 shared K. MichalskaiD· 3 shared Mateusz WilamowskiiD· 3 shared Robert P. JedrzejczakiD· 3 shared Youngchang KimiD· 3 shared Adam GodzikiD· 1 shared Alex LavensiD· 1 shared Changsoo ChangiD· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersMolecular Biology

A. JoachimiakORCID

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3 papers

Recent·Most cited

Molecular BiologyProceedings of the National Academy of SciencesPeer-reviewedMay 10, 2021

Methylation of RNA Cap in SARS-CoV-2 captured by serial crystallography

Mateusz Wilamowski, Darren A. Sherrell, G. Minasov…·A. Joachimiak

The paper determines the crystal structures of SARS-CoV-2 Nsp10/16 complexes before and after methylation, revealing the mechanism of RNA capping and its role in viral evasion of host defenses.

70 citationstop 4%

virusexperimental assay

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Molecular BiologyCommunications BiologyPeer-reviewedFeb 9, 2021

Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2

Youngchang Kim, Jacek Wower, N. Maltseva…·A. Joachimiak

The paper shows that Tipiracil inhibits SARS-CoV-2 Nsp15 by binding to its uridine site, supporting its potential as a drug scaffold for antiviral development.

129 citationstop 2%

experimental assaydrug response / drug discovery

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Molecular BiologyProtein SciencePeer-reviewedApr 18, 2020

Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV-2

Youngchang Kim, Robert P. Jedrzejczak, N. Maltseva…·A. Joachimiak

The paper reports the high-resolution crystal structure of SARS-CoV-2 Nsp15/NendoU and compares it with structures from SARS and MERS coronaviruses.

386 citationstop 1%

virusprotein structure

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