Robert P. Jedrzejczak

Cryo-EM structure of detergent-bound Vibrio cholerae MakA captures a candidate intermediate between the soluble form and mature assembly of an α-pore-forming toxin

The paper reports a cryo-EM structure of detergent-bound Vibrio cholerae MakA, revealing its conformational changes and role in pore assembly.

Methylation of RNA Cap in SARS-CoV-2 captured by serial crystallography

The paper determines the crystal structures of SARS-CoV-2 Nsp10/16 complexes before and after methylation, revealing the mechanism of RNA capping and its role in viral evasion of host defenses.

Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2

The paper shows that Tipiracil inhibits SARS-CoV-2 Nsp15 by binding to its uridine site, supporting its potential as a drug scaffold for antiviral development.

Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors

This paper reports structural and biochemical studies of SARS-CoV-2 papain-like protease and its complexes with inhibitors, showing their ability to inhibit enzyme activity and viral replication.

Crystal structures of SARS-CoV-2 ADP-ribose phosphatase (ADRP): from the apo form to ligand complexes

The paper determines crystal structures of SARS-CoV-2 ADRP and shows conformational changes upon ligand binding, identifying a conserved water molecule involved in hydrolysis.

Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV-2

The paper reports the high-resolution crystal structure of SARS-CoV-2 Nsp15/NendoU and compares it with structures from SARS and MERS coronaviruses.