Yuan Yuan

Human transcription factor combinations mapped by footprinting with deaminase

The paper introduces a method to map transcription factor binding sites genome-wide with single-base resolution and applies it to study cell-type-specific TF cooperativity in human tissues.

Single-cell proteomics of pre-implantation mouse embryos uncovers distinct asymmetry of certain proteins among early blastomeres

The paper uses single-cell proteomics to show protein asymmetry in mouse blastomeres, independent of RNA expression, revealing a new mechanism for early cell fate determination.

Correlated Protein Modules Revealing Functional Coordination of Interacting Proteins are Detected by Single-cell Proteomics

The paper uses single-cell proteomics to detect correlated protein modules (CPMs) that reveal functional coordination of interacting proteins in mammalian cells.