Yinghui Zheng

The paper introduces Joint-Cabernet, a single-cell platform for profiling 5hmC and 5mC, and applies it to mouse brain nuclei to study DNA hydroxymethylation changes with aging.

The paper introduces a method to map transcription factor binding sites genome-wide with single-base resolution and applies it to study cell-type-specific TF cooperativity in human tissues.

The paper uses single-cell proteomics to show protein asymmetry in mouse blastomeres, independent of RNA expression, revealing a new mechanism for early cell fate determination.

The paper introduces Cabernet, a bisulfite-free single-cell method for high-resolution 5mC and 5hmC profiling, revealing epigenetic dynamics in mouse embryos and demonstrating scalability for complex tissues.

The paper uses single-cell proteomics to detect correlated protein modules (CPMs) that reveal functional coordination of interacting proteins in mammalian cells.

The paper generates transcriptome and 3D genome atlases of developing mouse brain cells, revealing structure-type-based cell identity and experience-independent developmental changes.

The paper reports the cryo-EM structure of a potent SARS-CoV-2 NAb, BD-368-2, showing it blocks ACE2 binding and induces structural changes in the spike trimer, distinct from other NAbs.