The paper identifies estrogen-modulated SNVs associated with breast cancer risk and shows their interaction with reproductive factors using polygenic risk scores.

medRxiv · Sep 11, 2026 · PreprintGenetic & Genomic Medicine

The Adhesion GPCR ADGRL2 engages Gα13 to Enable Epidermal Differentiation

Xue Yang, Feng He, Vanessa Lopez-Pajares, Douglas F. Porter, Krassimira A. Garbett, Zurab Siprashvili, Luca Ducoli, Robin M. Meyers, David L. Reynolds, Duy Lan Huong Bui, Audrey W. Hong, Thanh Nguyen, Yuqing Jing, Smarajit Mondal, Lisa A. Ko, , Paul A. Khavari

The paper identifies ADGRL2's role in epidermal differentiation through Gα13 activation and structural interactions, using CRISPR, Perturb-seq, and cryo-EM.

Proceedings of the National Academy of Sciences · Nov 18, 2025Peer-reviewedCell Biology

Disease-Linked Regulatory DNA Variants and Homeostatic Transcription Factors in Epidermis

Douglas F. Porter, Robin M. Meyers, Weili Miao, David L. Reynolds, Audrey W. Hong, Xue Yang, Suhas Srinivasan, Smarajit Mondal, Zurab Siprashvili, Tania Fabo, Ronghao Zhou, Tri C. Nguyen, Luca Ducoli, Jordan M. Meyers, Duy T. Nguyen, , Paul A. Khavari

The paper identifies disease-linked regulatory DNA variants and their impact on epidermal homeostasis by analyzing SNVs, TF binding, and gene dysregulation in polygenic skin diseases.

Nature Communications · Sep 25, 2025Peer-reviewedGenetics