Xue Yang

Estrogen interactions with breast cancer risk variants in regulatory DNA

The paper identifies estrogen-modulated SNVs associated with breast cancer risk and shows their interaction with reproductive factors using polygenic risk scores.

The Adhesion GPCR ADGRL2 engages Gα13 to Enable Epidermal Differentiation

The paper identifies ADGRL2's role in epidermal differentiation through Gα13 activation and structural interactions, using CRISPR, Perturb-seq, and cryo-EM.

Disease-Linked Regulatory DNA Variants and Homeostatic Transcription Factors in Epidermis

The paper identifies disease-linked regulatory DNA variants and their impact on epidermal homeostasis by analyzing SNVs, TF binding, and gene dysregulation in polygenic skin diseases.

Interactions Between Dietary Metabolites and Regulatory Risk Variants for Human Colon Cancer

The paper studies how dietary metabolites interact with genetic variants to influence colon cancer risk through transcriptional regulation.

In vivo CRISPRi screen identified lncRNA portfolio crucial for cutaneous squamous cell carcinoma tumor growth

The paper identifies lncRNAs crucial for cSCC tumor growth using CRISPRi screens and single-cell sequencing.

Glucose modulates transcription factor dimerization to enable tissue differentiation

This study shows glucose acts as a morphogen that modulates transcription factor dimerization during tissue differentiation.