The Adhesion GPCR ADGRL2 engages Gα13 to Enable Epidermal Differentiation
Xue Yang, Feng He, Vanessa Lopez-Pajares, Douglas F. Porter, Krassimira A. Garbett, Zurab Siprashvili, Luca Ducoli, Robin M. Meyers, David L. Reynolds, Duy Lan Huong Bui, Audrey W. Hong, Thanh Nguyen, Yuqing Jing, Smarajit Mondal, Lisa A. Ko, , Paul A. Khavari
The paper identifies ADGRL2's role in epidermal differentiation through Gα13 activation and structural interactions, using CRISPR, Perturb-seq, and cryo-EM.
Proceedings of the National Academy of Sciences · Nov 18, 2025Peer-reviewedCell Biology