Douglas F. Porter

The paper identifies estrogen-modulated SNVs associated with breast cancer risk and shows their interaction with reproductive factors using polygenic risk scores.

The paper identifies ADGRL2's role in epidermal differentiation through Gα13 activation and structural interactions, using CRISPR, Perturb-seq, and cryo-EM.

The paper identifies disease-linked regulatory DNA variants and their impact on epidermal homeostasis by analyzing SNVs, TF binding, and gene dysregulation in polygenic skin diseases.

This study identifies glucose-binding proteins TSC22D4 and IGF2BP2 using thermal proteome profiling, showing their roles in metabolic disease and insulin secretion.

The paper introduces irCLIP-RNP and Re-CLIP methods to identify dynamic RNA-protein assemblies, revealing new patterns of RBP-RNA associations and EGF-induced remodeling.

The paper identifies iron-sensitive RNA regulation by poly C binding proteins through transcriptome analysis under low iron conditions.

This paper improves the easyCLIP protocol by addressing its limitations and providing a more reproducible analysis workflow.

The paper identifies RNA localization by covalently tagging RNAs near a uridine-adding enzyme anchored at specific subcellular sites, revealing conserved dual localization of RNAs across species.

easyCLIP quantifies RNA-protein interactions and identifies recurrent PCBP1 mutations in cancer by measuring RNA cross-link rates per protein.

The paper identifies gamete-specific and gamete-independent FBF targets in C. elegans germlines using FBF iCLIP data and clusters them into functional blocks.

The paper identifies FOG-3 as a Tob/BTG protein that forms polymers to regulate sperm fate in nematodes through RNA binding.