Author

Shelby M. Phelps

The University of Texas at DallasORCID 0000-0002-2885-189XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 3 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:protein design· 3 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Organism:E. coli· 1 Assay:fluorescence / live-cell microscopy· 1 Assay:protein structure· 1

Frequent Co-Authors

Jasmine N. TutoliD· 4 shared Sheel C. DodaniiD· 4 shared Weicheng PengiD· 2 shared Alice R. WalkeriD· 1 shared Caden MaydewiD· 1 shared Faruck MorcosiD· 1 shared Hiu C. KamiD· 1 shared Hsichuan ChiiD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersBiochemistry

Jasmine N. TutolORCID

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4 papers

Recent·Most cited

An All-Optical Approach to Probe Chloride Transport with a Bright ChlorON

Jasmine N. Tutol, Vishaka Pathiranage, Shelby M. Phelps, Alice R. Walker, Sheel C. Dodani

The paper introduces an improved fluorescent protein indicator, ChlorON-1-PRO, for real-time imaging of chloride transport in cells.

bioRxiv · Sep 17, 2026 · PreprintBiochemistry

NitrOFF: An engineered fluorescent biosensor to illuminate nitrate transport in living cells

Mariah A. Cook, Jonathan D. Smailys, Ke Ji, Shelby M. Phelps, Jasmine N. Tutol, Wantae Kim, Whitney S. Y. Ong, Weicheng Peng, Caden Maydew, Yan Zhang, Sheel C. Dodani

The paper introduces NitrOFF, a fluorescent biosensor for real-time nitrate detection in mammalian cells, showing it responds to nitrate with a turn-off fluorescence mechanism.

Angewandte Chemie International Edition · Aug 26, 2025Peer-reviewedBiochemistry

Directed Evolution of a Genetically Encoded Indicator for Chloride

Weicheng Peng, Jasmine N. Tutol, Shelby M. Phelps, Hiu C. Kam, Jacob K. Lynd, Sheel C. Dodani

The paper uses directed evolution to create a chloride-sensitive fluorescent protein indicator called ChlorOFF by mutating OFPxm.

ACS Synthetic Biology · Mar 21, 2025Peer-reviewedBiochemistry

Coupling a Live Cell Directed Evolution Assay with Coevolutionary Landscapes to Engineer an Improved Fluorescent Rhodopsin Chloride Sensor

Hsichuan Chi, Qin Zhou, Jasmine N. Tutol, Shelby M. Phelps, Jessica Lee, Paarth Kapadia, Faruck Morcos, Sheel C. Dodani

The paper engineers an improved fluorescent chloride sensor using directed evolution and coevolutionary analysis in E. coli.

ACS Synthetic Biology · Apr 7, 2022Peer-reviewedSynthetic Biology