Molecular basis of tRNA modification by the human m5C methyltransferase NSUN2
Elodie Carmen Leroy, Michelangelo Lassandro, Arianna Di Fazio, Alessio Di Ianni, Kanhaya Lal, Jon Rodriguez-Villa, Alice Rossi, Andrea Graziadei, Monika Gullerová, Ana Casañal
This study determines the structure of the NSUN2-tRNA complex and reveals how NSUN2 recognizes and modifies tRNA through RNA architecture and specific amino acid interactions.
bioRxiv · Mar 18, 2026 · PreprintMolecular Biology