Arianna Di Fazio

The paper reveals the structural basis of hDicer-tRNA complex formation and shows that m5C modification facilitates tRNA cleavage by hDicer.

This study determines the structure of the NSUN2-tRNA complex and reveals how NSUN2 recognizes and modifies tRNA through RNA architecture and specific amino acid interactions.

This study shows NSUN2 facilitates DICER cleavage of DARTs-associated R-loops to promote DNA repair after damage.

The paper shows that svtRNA1-2, a Dicer-dependent small vault RNA, modulates expression of cell membrane proteins by silencing nascent RNA through specific hybridization features.