Monika Gullerová

Structural and functional basis of the non-canonical human Dicer-tRNA complex

The paper reveals the structural basis of hDicer-tRNA complex formation and shows that m5C modification facilitates tRNA cleavage by hDicer.

Molecular basis of tRNA modification by the human m5C methyltransferase NSUN2

This study determines the structure of the NSUN2-tRNA complex and reveals how NSUN2 recognizes and modifies tRNA through RNA architecture and specific amino acid interactions.

NSUN2 Facilitates DICER Cleavage of DNA Damage-Associated R-Loops to Promote Repair

This study shows NSUN2 facilitates DICER cleavage of DARTs-associated R-loops to promote DNA repair after damage.

Tetrameric INTS6-SOSS1 complex facilitates DNA:RNA hybrid autoregulation at double-strand breaks

The paper identifies the tetrameric INTS6-SOSS1 complex as essential for DNA:RNA hybrid autoregulation at double-strand breaks, facilitating DNA repair through PP2A recruitment and DARTs prevention.

TIRR regulates mRNA export and association with P bodies in response to DNA damage

This study shows TIRR binds specific mRNAs and interacts with XPO1 and P bodies during DNA damage, aiding mRNA export and DNA repair.

Y RNA-derived fragments in a complex with YBX1 modulate PARP1 residency at DNA double strand breaks

The paper shows Y RNA-derived fragments packaged with YBX1 enhance PARP1 residency at DNA double strand breaks, improving DNA repair and cell survival through ADP-ribosylation.

GATAD2B containing NuRD complex drives R-loop dependent chromatin boundary formation at double strand breaks

This study shows the GATAD2B-NuRD complex regulates chromatin boundaries at DSBs by promoting histone deacetylation and condensation, essential for proper DNA repair.

Phosphorylated trimeric SOSS1 complex and RNA polymerase II trigger liquid-liquid phase separation at double-strand breaks

The paper shows that the SOSS1 complex and RNA polymerase II form phase-separated compartments at double-strand breaks to facilitate DNA repair.

Small non-coding vault RNA1-2 modulate expression of cell membrane proteins through nascent RNA silencing

The paper shows that svtRNA1-2, a Dicer-dependent small vault RNA, modulates expression of cell membrane proteins by silencing nascent RNA through specific hybridization features.