Elodie Carmen Leroy

Structural basis of Mycobacterium Fluoroquinolone Resistance Protein D (MfpD), a versatile pathogeny protein from the mfp conservon of Mycobacterium tuberculosis

This study defines the structural basis of MfpD function using phylogenetic, structural, and biophysical approaches, revealing its role in promoting GTP hydrolysis by MfpB through a noncanonical mechanism.

Molecular basis of tRNA modification by the human m5C methyltransferase NSUN2

This study determines the structure of the NSUN2-tRNA complex and reveals how NSUN2 recognizes and modifies tRNA through RNA architecture and specific amino acid interactions.

Tetracenomycin X sequesters peptidyl-tRNA during translation of QK motifs

The paper identifies how tetracenomycin X inhibits bacterial translation by sequestering peptidyl-tRNA at QK motifs, revealing a novel mechanism for antibiotic action.