Vinay Kumar Nandicoori

Sec and Tat mediated secretion safeguards Mycobacterium tuberculosis membrane homeostasis

This study identifies SecA1 and TatA as critical for Mycobacterium tuberculosis membrane integrity through multi-omics and functional genetics analyses.

PE11 promotes intracellular persistence of Mycobacterium tuberculosis by inhibiting autophagy and lysosomal biogenesis by targeting the FLCN-lactate-TFEB signaling axis

This study identifies PE11 as a factor that promotes Mtb persistence by inhibiting autophagy and lysosomal biogenesis through the FLCN-lactate-TFEB signaling axis, with lactate shown to enhance bacterial clearance.

Structure-function relationship of PE11 esterase of Mycobacterium tuberculosis with respect to its role in virulence

This study characterizes the structure and function of PE11 esterase from Mycobacterium tuberculosis, showing its role in virulence and potential as a therapeutic target.

Wag31, a membrane tether, is crucial for lipid homeostasis in mycobacteria

This study identifies Wag31's role in lipid homeostasis in mycobacteria by showing its tethering activity and interactions with membrane proteins.

A clinical mutation in uvrA, a DNA repair gene, confers survival advantage to Mycobacterium tuberculosis in the host

The paper identifies a Q135K mutation in uvrA of Mycobacterium tuberculosis that confers survival advantage under oxidative stress and in macrophages, enhancing host adaptability.

A Mycobacterium tuberculosis secreted virulence factor disrupts host snRNP biogenesis

This paper identifies a Mycobacterium tuberculosis secreted protein that disrupts host snRNP biogenesis, altering RNA splicing and contributing to pathogenesis.