Neeraj Dhar

Human prostaglandin reductases dearomatize and inactivate benzothiazinone antitubercular drugs

The paper shows human prostaglandin reductases PTGR1 and PTGR2 inactivate the antitubercular drug MCZ by dearomatizing it into H2MCZ, reducing its antimycobacterial activity.

A genetically encoded biosensor reveals heterogenous cAMP dynamics coordinating growth and resuscitation in Mycobacterium tuberculosis

This paper develops a genetically encoded biosensor, rmgCarvi, to monitor cAMP dynamics in Mycobacterium tuberculosis at single-cell resolution, revealing how cAMP levels coordinate growth and resuscitation in response to nutrient availability and host environments.

Menaquinone depletion resensitises bedaquiline-resistant tuberculosis

This study identifies MenG inhibitors that restore bedaquiline susceptibility in resistant tuberculosis strains through menaquinone pathway disruption.

Wag31, a membrane tether, is crucial for lipid homeostasis in mycobacteria

This study identifies Wag31's role in lipid homeostasis in mycobacteria by showing its tethering activity and interactions with membrane proteins.

Impact of cell culture model systems on SARS-CoV-2 and MERS-CoV infection dynamics and antiviral responses

This study compares SARS-CoV-2 and MERS-CoV infection dynamics and antiviral responses in primary lung organoid-derived monolayers and air-liquid interface cultures, finding that ALI cultures better capture viral infection and immune responses.