Henry N. Higgs

Regulation of the formin INF2 by actin monomers and calcium-calmodulin

This study investigates INF2 regulation by calcium-calmodulin and actin monomers, showing that actin monomer-binding proteins are essential for INF2 activation and regulation.

Peri-mitochondrial actin filaments inhibit Parkin assembly via disruption of ER-mitochondrial contact

The paper shows that peri-mitochondrial actin filaments (ADA) inhibit Parkin assembly by disrupting ER-mitochondrial contacts, delaying mitophagy after acute damage and blocking it during chronic dysfunction.

The tumour suppressor LACTB remodels mitochondria to promotecytochrome c release and apoptosis

This study identifies LACTB as a regulator of inner mitochondrial membrane dynamics during apoptosis, promoting cytochrome c release and apoptosis by remodeling cardiolipin-enriched membrane nanotubes.

Missense Mutant Gain-of-Function Causes Inverted Formin 2 (INF2)-Related Focal Segmental Glomerulosclerosis (FSGS)

This study shows that a gain-of-function INF2 mutation causes FSGS in mice, linking INF2's cellular roles to disease progression and explaining its autosomal dominant inheritance.

Actin enhances ER-mitochondrial calcium transfer and IMM constriction during mitochondrial division

The paper shows actin polymerization via INF2 enhances ER-mitochondrial calcium transfer and IMM constriction during mitochondrial division, independent of Drp1.