Self-organized morphogenesis of a human neural tube in vitro by geometric constraints
Eyal Karzbrun, Aimal H. Khankhel, Heitor C. Megale, Stella M.K. Glasauer, Yofiel Wyle, George Britton, Aryeh Warmflash, Kenneth S. Kosik, Eric D. Siggia, Boris I. Shraiman, Sebastian J. Streichan
This paper describes an in vitro method to self-organize a human neural tube using geometric constraints, showing that neural and epidermal tissues are sufficient for morphogenesis.
Nature · Oct 27, 2021Peer-reviewedDevelopmental Biology