Author

Heitor C. Megale

Harvard University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Approach:machine learning (classical)· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Giridhar M. Anand· 2 shared Sharad RamanathaniD· 2 shared Aimal H. Khankhel· 1 shared Aryeh WarmflashiD· 1 shared Boris I. ShraimaniD· 1 shared Chudi Abraham-Igwe· 1 shared Eric D. SiggiaiD· 1 shared Eyal KarzbruniD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersDevelopmental Biology

Giridhar M. Anand

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3 papers

Recent·Most cited

Arrayed single-gene perturbations identify drivers of human anterior neural tube closure

Roya E. Huang, Giridhar M. Anand, Heitor C. Megale, Jason Chen, Chudi Abraham-Igwe, Sharad Ramanathan

The paper develops a platform for high-throughput CRISPRi screening in hPSC-derived organoids to identify genetic drivers of human anterior neural tube closure, finding ZIC2, SOX11, and ZNF521 as key regulators.

eLife · Jul 7, 2026Peer-reviewedDevelopmental Biology

Machine learning directed organoid morphogenesis uncovers an excitable system driving human axial elongation

Giridhar M. Anand, Heitor C. Megale, Sean H. Murphy, Theresa Weis, Zuwan Lin, Yichun He, Xiao Wang, Jia Liu B, Sharad Ramanathan

This study uses machine learning to optimize organoid morphogenesis, revealing an excitable system driven by WNT and FGF signaling that governs human axial elongation.

Cell · Jan 18, 2023Peer-reviewedDevelopmental Biology

Self-organized morphogenesis of a human neural tube in vitro by geometric constraints

Eyal Karzbrun, Aimal H. Khankhel, Heitor C. Megale, Stella M.K. Glasauer, Yofiel Wyle, George Britton, Aryeh Warmflash, Kenneth S. Kosik, Eric D. Siggia, Boris I. Shraiman, Sebastian J. Streichan

This paper describes an in vitro method to self-organize a human neural tube using geometric constraints, showing that neural and epidermal tissues are sufficient for morphogenesis.

Nature · Oct 27, 2021Peer-reviewedDevelopmental Biology