Sebastian J. Streichan

Blender tissue cartography provides an intuitive tool for analyzing dynamic 3D microscopy data by converting complex 3D tissues into 2D projections for easier visualization and analysis.

The paper reveals that stationary and germ-layer-specific tissue flows shape the zebrafish gastrula through in toto live imaging and analysis.

This study shows that YAP overactivation in HCM mutant cardiomyocytes drives hypertrophy via CCN2 secretion and TGFβ uptake.

The paper uses machine learning to model BMP-driven cytoskeletal dynamics in Drosophila development and shows its conservation in human neuroectoderm morphogenesis.

The paper shows that topological spindle-spindle interactions, not internuclear distance, control spindle orientation and nuclear fate in Drosophila embryos.

The paper shows cell divisions drive fourfold orientationally ordered tissue phases in Parhyale hawaiensis embryos through active defect climb mechanisms.

The paper investigates how myosin-II orientation is geometrically controlled during axis elongation in D. melanogaster embryos, showing that myosin anisotropy remains static while gene expression deforms.

The paper investigates how mechanical feedback establishes a global myosin gradient during Drosophila embryogenesis through dynamic recruitment and mathematical modeling.

The paper constructs a morphodynamic atlas integrating fixed and live datasets to study tissue dynamics and gene expression during Drosophila development.

The paper studies how multi-layer tissue interactions drive organ shape changes in Drosophila embryos, identifying calcium-patterned muscle contractions as a key mechanism.

The paper introduces scMAT-seq, a single-cell multiomics method, to study epigenetic regulation during human gastrulation and germ cell development in 3D organoids, revealing insights into DNA methylation and accessibility dynamics.

This paper describes an in vitro method to self-organize a human neural tube using geometric constraints, showing that neural and epidermal tissues are sufficient for morphogenesis.

The paper deconstructs early gastrulation stages in Drosophila embryos by analyzing cell shape changes, divisions, and intercalations using computational methods.

The paper investigates how Drosophila border cells integrate chemical and physical cues during migration, showing that tissue topography significantly influences path selection.

The paper identifies Dynamic Morphoskeletons (DM) from cell velocity data to analyze tissue organization during development, revealing spatial attractors and repellers in chicken and fly embryos.

The paper shows that EGFR signaling coordinates patterning with cell survival in Drosophila epidermis by regulating pro-apoptotic gene expression based on ligand availability.

The paper investigates how basement membrane stiffness influences tissue elongation in Drosophila follicles through mechanosensitive junctional remodeling.