Author

Xiao Yan

Capital Medical UniversityORCID 0000-0002-2933-7702Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:deep learning· 1 Approach:diffusion model· 1 Approach:experimental assay· 1 Research Focus:protein design· 1 Assay:protein structure· 1

Frequent Co-Authors

Anthony A. HymaniD· 2 shared Aleksandra V. SergeevaiD· 1 shared Alex KangiD· 1 shared An‐Qi CheniD· 1 shared Asim K. BeraiD· 1 shared Benjamí Oller‐SalviaiD· 1 shared Brian CoventryiD· 1 shared Casey Welch· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCell Biology

Anthony A. HymanORCID

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2 papers

Recent·Most cited

Redox surveillance of stress granules prevents TDP-43 aggregation

Xiao Yan, Silja Zedlitz, Xuemeng Chen, Yi-Cheng Tsai, Yuefeng Ma, Michael Chen, Linge Li, David Kuster, Jik Nijssen, Aleksandra V. Sergeeva, Yiyang Chen, Casey Welch, Wen Yu, Zongru Li, Marco Messina, , Anthony A. Hyman

This study shows that redox surveillance in stress granules prevents TDP-43 aggregation by maintaining a controlled redox environment.

bioRxiv · Oct 19, 2026 · PreprintCell Biology

Computational design of metalloproteases

An‐Qi Chen, Kejia Wu, Hojae Choi, Preetham Venkatesh, Samuel J. Pellock, Nikita Hanikel, Hojeong Shin, Declan Evans, Kieran Didi, Lars L Schaaf, Cristina Díaz‐Perlas, Brian Coventry, Donghyo Kim, Seth M. Woodbury, Pengfei Ji, , David A. Baker

This paper designs de novo metalloproteases using RoseTTAFold Diffusion 2, achieving high activity and specificity for cleaving various substrates.

Nature · Oct 14, 2026Peer-reviewedBiochemistry