Hojae Choi

De novo design of cysteine proteases

This study designs de novo cysteine proteases with high activity and structural novelty, achieving 19% success rate and up to 3 x 10^7 rate enhancement over background reactions.

Computational design of metalloproteases

This paper designs de novo metalloproteases using RoseTTAFold Diffusion 2, achieving high activity and specificity for cleaving various substrates.

De novo design of allosterically controlled enzymes

This study designs allosterically controlled enzymes using denoising diffusion models, showing that activity can be activated or repressed by designed effectors.