Francesca Telese

This paper expands the RatGTEx resource with transcriptome-wide associations across 3,160 RNA-seq samples, identifying 7,473 gene-trait links and 144,876 QTLs for 22,599 genes.

The paper identifies genetic factors associated with balance in the elderly through GWAS and multimodal transcriptomic analysis of otolithic organs.

This study shows Reelin regulates retinal lamination by coordinating neuronal positioning and Müller glia scaffold maturation in mice.

Trex-QTL identifies trans-eQTLs with global effects on molecular phenotypes, showing improved power and replicating known loci in rat brain data.

This study identifies time-dependent epistatic interactions between Oprm1 and Fgf12 that modulate opioid-induced locomotion in mice and links Fgf12 to opioid behavior in humans.

This study maps transcription initiation in mouse astrocytes to define how inflammatory signals drive cell-type-specific gene regulation and links enhancer activity to human disease risk.

The paper develops FEDUPP, an open-source analysis pipeline, to assess learning and cognitive flexibility in mice using a home-cage paradigm, revealing subtle impairments in goal-directed feeding behavior.

This study shows that Reln haploinsufficiency increases fentanyl-induced locomotion and striatal activity but does not affect opioid reinforcement or relapse-like behavior.

This study shows that perinatal fentanyl exposure in rats leads to long-term addiction risk and central amygdala gene dysregulation, providing insights into the molecular mechanisms of NOWS and its consequences.

This study examines the long-term neurobehavioral and neurochemical effects of adolescent 5F-MDMB-PICA IV self-administration in mice, showing increased aggression, reduced social interaction, and mPFC dysfunction in adulthood.

This study uses single-nucleus RNA sequencing to show that adolescent THC exposure and reduced Reelin signaling both affect nucleus accumbens maturation through shared gene networks linked to substance use and psychiatric disorders.

The paper presents an improved rat reference genome, mRatBN7.2, which enhances genomic, transcriptomic, and proteomics data mapping and identifies millions of genetic variations across rat strains.

The paper identifies cell type-specific gene regulatory changes in the amygdala of rats with varying cocaine addiction-like behaviors, linking them to energy metabolism, GABAergic inhibition, and chromatin accessibility.

This study examines sex-biased gene expression changes in mouse brain regions after adolescent THC exposure, identifying common regulatory mechanisms linked to cannabis use disorder vulnerability.

This study shows that Reelin deficiency increases cocaine-induced hyperlocomotion in mice by enhancing neuronal activity in the dorsomedial striatum, without affecting cocaine reward.

The paper investigates how drug exposure alters gene regulatory networks in the brain using multi-omics approaches, identifying enhancer repression and transcription factor involvement in addiction-related behaviors.

This study shows that Reelin deficiency exacerbates long-term behavioral issues in mice exposed to THC during adolescence, including impaired social behavior and increased novelty seeking.