Steve J. Gamblin

This study shows G4 RNA inhibits PRC2 by binding to disordered loops in EZH2, preventing nucleosome interaction and modulated by SAM and peptides.

This study reports the structures of a mammalian gamma-CoV spike in closed and open conformations, revealing conserved mechanisms of spike dynamics and lipid binding's role in stabilizing the closed state.

The paper evaluates neutralising antibody titres against SARS-CoV-2 variant JN.1 using live-virus microneutralisation assays in vaccinated individuals, finding higher titres in monovalent vaccine recipients.

The paper identifies a novel ACE2 isoform, LTR16A1-ACE2, induced by interferon, which is non-functional and does not enhance SARS-CoV-2 infection.