Zinc Finger Repressors mediate widespread PRNP lowering in the nonhuman primate brain and profoundly extend survival in prion disease mice
Shih-Wei Chou, Meredith A Mortberg, Kimberly Marlen, David S. Ojala, Toufan Parman, Michael Howard, Kendrick DeSouza-Lenz, Yuan Lian, Mohadeseh Mehrabian, Matthew R. Tiffany, Annemarie Ledeboer, Patrick Dunn, Jing Hu, Kenia Guzman, Nikita Kamath, , Bryan Zeitler
This study demonstrates that Zinc Finger Repressors (ZFRs) reduce prion protein (PrP) expression in nonhuman primates and extend survival in prion disease mice.
bioRxiv · Mar 5, 2025 · PreprintNeuroscience