Dongjun Ren

This study identifies epidermal Langerhans cells as key contributors to painful diabetic neuropathy, revealing sex-dependent roles in mechanical allodynia and pain behavior.

The paper develops a method combining automated patch clamp and optogenetics to selectively record from specific subtypes of mouse DRG neurons.

The paper introduces a standardized, open-source protocol for noninvasive joint injury in mice, resulting in post-traumatic osteoarthritis, and provides tools for reproducibility and analysis.

This study identifies sensory fiber types in mouse TMJ tissues using immunohistochemistry, finding peptidergic fibers dominate with minimal non-peptidergic nociceptors.

This study shows that inhibiting Piezo2 reduces acute inflammatory and osteoarthritis knee pain in mice using FM-dyes.

This study investigates keratinocyte-derived exosomes in a mouse model of painful diabetic neuropathy, finding differences in their molecular content and showing retrograde trafficking to DRG neurons.

The paper identifies Mrgprd-expressing DRG neurons as a driver of pain hypersensitivity in a mouse model of PDN and shows targeting these neurons can reverse mechanical allodynia.

This study identifies the cellular distribution of matrisome genes in murine and human dorsal root ganglia, revealing their potential role in neuronal signaling and pain.