Keisuke Aoshima

Sulfoquinovosylacylpropanediol monotherapy suppresses canine hemangiosarcoma patient-derived xenograft models with vascular remodeling

This study shows that SQAP reduces tumor growth in canine HSA PDX models by altering vascular and macrophage-related tumor microenvironment features, not through direct cytotoxicity.

Lactate dehydrogenase is associated with cholesterol/lipid metabolism, and fluvastatin plus dipyridamole suppresses canine hemangiosarcoma growth in patient-derived xenograft models

This study shows that lactate dehydrogenase (LDH) is linked to cholesterol/lipid metabolism in canine hemangiosarcoma, and that combining fluvastatin and dipyridamole inhibits tumor growth in xenograft models.

Lysine lactylation regulates ATF4-mediated stress responses under glucose starvation in canine hemangiosarcoma

This study shows lysine lactylation at stress-response gene TSSs is enriched under glucose starvation in canine hemangiosarcoma and correlates with transcriptional activation.