ImmunologymAbsPeer-reviewed
Tuning antibody stability and function by rational designs of framework mutations
Joseph Chi-Fung Ng, Alicia M. Chenoweth, Maria Laura De Sciscio…·Franca Fraternali
This study designs framework mutations in antibodies to improve stability and function using a computational-experimental approach, showing that FW modifications can affect immunological functions beyond binding affinity.
3 citations