Author

Alicia M. Chenoweth

Guy's HospitalORCID 0000-0002-2736-9268Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

Alexandra J. McCrawiD· 1 shared Alice Kosmider· 1 shared Anthony CheungiD· 1 shared Claire M. MilleriD· 1 shared Daniela IancuiD· 1 shared Domenic P. J. GermanoiD· 1 shared Dongjun GuoiD· 1 shared Franca FraternaliiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperImmunology

Alexandra J. McCrawORCID

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2 papers

Recent·Most cited

Mathematical modelling of macrophage and natural killer cell immune response during early stages of peritoneal endometriosis lesion onset

Claire M. Miller, Domenic P. J. Germano, Alicia M. Chenoweth, Sarah J. Holdsworth‐Carson

This study develops a mathematical model of immune responses in early endometriosis, showing reduced cytotoxicity and detection ability drive disease onset.

Journal of The Royal Society Interface · Aug 1, 2025Peer-reviewedSystems Biology

Tuning antibody stability and function by rational designs of framework mutations

Joseph Chi-Fung Ng, Alicia M. Chenoweth, Maria Laura De Sciscio, Melanie Grandits, Anthony Cheung, Tooki Chu, Alexandra J. McCraw, Jitesh Chauhan, Yi Liu, Dongjun Guo, Semil Patel, Alice Kosmider, Daniela Iancu, Sophia N. Karagiannis, Franca Fraternali

This study designs framework mutations in antibodies to improve stability and function using a computational-experimental approach, showing that FW modifications can affect immunological functions beyond binding affinity.

mAbs · Jul 13, 2025Peer-reviewedImmunology