Author

Maria Laura De Sciscio

Sapienza University of RomeORCID 0000-0001-5523-0987Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Organism:plant (other)· 1

Frequent Co-Authors

Franca FraternaliiD· 2 shared Adrien MahleriD· 1 shared Alberto Barbiroli· 1 shared Alex FissoreiD· 1 shared Alexandra J. McCrawiD· 1 shared Alice Kosmider· 1 shared Alicia M. ChenowethiD· 1 shared Andrea Caratti· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiochemistry

Franca FraternaliORCID

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3 papers

Recent·Most cited

BiochemistrybioRxivPreprintMay 16, 2026

Molecular determinants of Bcl-xL membrane insertion - Structural plasticity exploration in solution and in nanodiscs identifies IsoAsp deamidation as a loss-of function mechanism in vivo.

Joann Kervadec, Maria Laura De Sciscio, Adrien Mahler…·Muriel Priault

DOI 10.64898/2026.05.14.725174

humanproteomics

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BiochemistryInternational Journal of Biological MacromoleculesPeer-reviewedAug 5, 2025

Corylus avellana non-specific lipid-transfer protein Cor a 8 is a moonlighting enzyme with a new lipase activity

Alex Fissore, Giulia Di Napoli, Maria Laura De Sciscio…·Salvatore Adinolfi

This study identifies Cor a 8, a non-specific lipid-transfer protein, as a novel lipase in hazelnuts that hydrolyzes triglycerides and contributes to lipid oxidation.

3 citations

plant (other)proteomics

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ImmunologymAbsPeer-reviewedJul 13, 2025

Tuning antibody stability and function by rational designs of framework mutations

Joseph Chi-Fung Ng, Alicia M. Chenoweth, Maria Laura De Sciscio…·Franca Fraternali

This study designs framework mutations in antibodies to improve stability and function using a computational-experimental approach, showing that FW modifications can affect immunological functions beyond binding affinity.

3 citations

protein structuredeep learning

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