Dongjun Guo

ImmunoMatch predicts cognate pairing of heavy and light immunoglobulin chains using a language model trained on paired sequences from human B cells.

This study designs framework mutations in antibodies to improve stability and function using a computational-experimental approach, showing that FW modifications can affect immunological functions beyond binding affinity.

The paper investigates antibody class switching dynamics in a primary human immune response, revealing multistep progression and memory B cell subtype dependence beyond IGHG2.

VCAb provides a web tool for antibody engineering by annotating antibody structures, isotypes, and mutation impacts across species.