Tuning antibody stability and function by rational designs of framework mutations
Joseph Chi-Fung Ng, Alicia M. Chenoweth, Maria Laura De Sciscio, Melanie Grandits, Anthony Cheung, Tooki Chu, Alexandra J. McCraw, Jitesh Chauhan, Yi Liu, Dongjun Guo, Semil Patel, Alice Kosmider, Daniela Iancu, Sophia N. Karagiannis, Franca Fraternali
This study designs framework mutations in antibodies to improve stability and function using a computational-experimental approach, showing that FW modifications can affect immunological functions beyond binding affinity.
mAbs · Jul 13, 2025Peer-reviewedImmunology