Author

Sarah Costantino

University of ZurichORCID 0000-0002-3003-7213Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Alessandro MengozziiD· 1 shared Era GoricaiD· 1 shared Francesco PaneniiD· 1 shared Frank Thomas RuschitzkaiD· 1 shared Gergely KarsaiiD· 1 shared Junyan XiaiD· 1 shared Kaivalya WalavalkariD· 1 shared Loek van HeerebeekiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperPhysiology

Alessandro MengozziORCID

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1 paper

Recent·Most cited

Chromatin Remodeling by the Histone Methyltransferase SETD2 Drives Lipotoxic Injury in Cardiometabolic Heart Failure with Preserved Ejection Fraction

Sarah Costantino, S. A. Mohammed, Samuele Ambrosini, Marialucia Telesca, Alessandro Mengozzi, Kaivalya Walavalkar, Era Gorica, Melissa Herwig, Loek van Heerebeek, Junyan Xia, Gergely Karsai, Thorsten Hornemann, Omer Dzemali, Raffaella Santoro, Qian Lin, , Francesco Paneni

This study shows that SETD2 promotes lipotoxic injury in cHFpEF by regulating SREBP1 and lipid metabolism, and its inhibition improves cardiac function.

Circulation Research · Apr 11, 2025Peer-reviewedPhysiology