Author

Pierre Barennes

InsermORCID 0000-0002-3017-0719Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:bulk RNA-seq· 4 Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Organism:human· 4 Approach:statistical model· 4 Research Focus:clustering· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Adrien SixiD· 3 shared David KlatzmanniD· 3 shared Encarnita Mariotti‐FerrandiziD· 3 shared Hélène VantommeiD· 3 shared Leslie AddaiD· 3 shared Nicolas CoatnoaniD· 3 shared Paul StysiD· 3 shared Vanessa MhannaiD· 3 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersImmunology

Adrien SixORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A regulatory T cell signature provides a shared molecular basis for the therapeutic window of opportunity in rheumatic disease

Marie Binvignat, Federica Martina, Fabien Pitoiset, Alexandra Roux, Roberta Lorenzon, Pierre Hodara, Pierre Barennes, Hélène Vantomme, Michèle Sastre, Signe Hässler, Claire Ribet, Alice Courties, Vanessa Mhanna, Paul Stys, Leslie Adda, , Encarnita Mariotti‐Ferrandiz

The paper identifies a shared Treg dysfunction signature across rheumatic diseases, suggesting a therapeutic window of opportunity for Treg-targeted treatments.

bioRxiv · Sep 27, 2026 · PreprintImmunology

Thymic selection of the T cell receptor repertoire is biased toward autoimmunity in females

Hélène Vantomme, Valentin Quiniou, Leslie Adda, Charline Jouannet, Vanessa Mhanna, Céline Albalaa, Pierre Barennes, Nicolas Coatnoan, Vimala Diderot, Johanna Dubois, Gwladys Fourcade, Kenz Le Gouge, Otriv Frédéric Nguekap Tchoumba, Martin Pezous, Paul Stys, , David Klatzmann

The paper identifies sex-specific differences in TCR selection during thymic development, showing female effector T cells have more autoimmunity-associated TCRs while female Tregs have fewer.

eLife · Aug 20, 2026Peer-reviewedSystems Biology

Immunological Profiling in Knee Osteoarthritis: Treg Dysfunction as Key Driver of Pain

Marie Binvignat, Johanna Dubois, Maria Marco Salvador, Paul Stys, Fabien Pitoiset, Alexandra Roux, Michèle Sastre, Signe Hässler, Roberta Lorenzon, Claire Ribet, Vanessa Mhanna, Hélène Vantomme, Leslie Adda, Pierre Barennes, Nicolas Coatnoan, , Jérémie Sellam

This study identifies Treg dysfunction as associated with OA-related pain through multi-omic analysis of peripheral blood from knee OA patients.

Arthritis & Rheumatology · Nov 14, 2025Peer-reviewedImmunology

Differential predictive value of resident memory CD8+T cell subpopulations in non-small-cell lung cancer patients treated by immunotherapy

Léa Paolini, Thi Tran, Stéphanie Corgnac, Jean-Philippe Villemin, Marie Wislez, Jennifer Arrondeau, Ludger Johannes, Jonathan Ulmer, Louis-Victorien Vieillard, Joséphine Pineau, Alain Gey, Valentin Quiniou, Pierre Barennes, Hang‐Phuong Pham, Nadège Gruel, , Éric Tartour

The paper identifies two TRM subpopulations in NSCLC patients and shows that only DP TRM predicts response to PD-1 blockade immunotherapy.

Journal for ImmunoTherapy of Cancer · Dec 1, 2024Peer-reviewedImmunology