Author

Johan Holmberg

Karolinska InstitutetORCID 0000-0002-3018-001XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Eirini AntoniouiD· 2 shared Erik SödersteniD· 2 shared Behzad Yaghmaeian SalmaniiD· 1 shared David YudovichiD· 1 shared Diahann A. M. AtachoiD· 1 shared Henrik LindehelliD· 1 shared Ilknur Safak Demirel· 1 shared Iria Laura MartineziD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

Eirini AntoniouORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cancer BiologyProceedings of the National Academy of SciencesPeer-reviewedOct 21, 2025

HIF2α negatively regulates MYCN protein levels and promotes a low-risk noradrenergic phenotype in neuroblastoma.

Juan Yuan, Subhamita Maitra, Eirini Antoniou…·Johan Holmberg

This paper shows that HIF2α reduces MYCN protein levels and promotes a low-risk noradrenergic phenotype in neuroblastoma, suggesting HIF2 has tumor suppressor rather than oncogenic function.

1 citation

humanbulk RNA-seq

𝕏 PostBluesky

NeuroscienceScience AdvancesPeer-reviewedAug 26, 2022

PRC2-mediated repression is essential to maintain identity and function of differentiated dopaminergic and serotonergic neurons

Konstantinos Toskas, Behzad Yaghmaeian Salmani, Olga Skiteva…·Johan Holmberg

This study shows that PRC2-mediated repression is essential for maintaining identity and function of dopaminergic and serotonergic neurons, with loss leading to behavioral deficits.

24 citations

mouseChIP-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintJul 7, 2020

Activation of endogenous retroviruses during brain development causes neuroinflammation

Marie E. Jönsson, Raquel Garza, Yogita Sharma…·Johan Jakobsson

This study shows that activation of endogenous retroviruses during brain development leads to neuroinflammation in adult mice.

3 citations

mouseexperimental assay

𝕏 PostBluesky