Amber M. Tetlow

This paper presents a single-domain antibody-based protein degrader that reduces tau levels and improves motor function in tauopathy models.

This study investigates neuronal function and network activity in early-stage tauopathy mice, finding hypofunction in motor cortical neurons and partial restoration with tau antibody treatment.

This paper develops a single-domain antibody-based protein degrader that enhances proteasomal and lysosomal degradation of α-synuclein in synucleinopathy models.