Ruimin Pan

A single-domain antibody targets aggregation-prone region of α-synuclein to reduce synucleinopathy, rescue neurodegeneration and improve function

This study evaluates five anti-α-synuclein single-domain antibodies in Drosophila models, identifying 2H1 as the most effective in reducing pathology and improving disease parameters.

Tau pSer396 and pSer404 Define Distinct Epitope Regions Linked to Different Antibody Functions

The paper compares pSer396- and pSer404-selective antibodies, showing differences in efficacy and structural binding modes, and highlights how humanization affects their therapeutic properties.

Single-Domain Antibody-Based Autophagosome-Targeting Chimera for Tau Clearance and Motor Function Restoration in Tauopathies

This paper presents a single-domain antibody-based protein degrader that reduces tau levels and improves motor function in tauopathy models.

Single-Domain Antibody-Based Protein Degrader for Synucleinopathies

This paper develops a single-domain antibody-based protein degrader that enhances proteasomal and lysosomal degradation of α-synuclein in synucleinopathy models.