Adrianne D. Gladden

The paper identifies an inducible microfold-like cell population in the colon associated with severe Clostridioides difficile infection susceptibility and shows its role in epithelial repair and immune response.

This study develops a co-culture system to study C. difficile interaction with human intestinal epithelium and finds CCL20 expression is upregulated in response to the bacterium.

The paper introduces DNA spike-ins to detect contamination in SARS-CoV-2 amplicon-based sequencing and demonstrates their utility in a real-world outbreak investigation.

HCR-FlowFISH identifies cis-regulatory elements and their target genes by quantifying gene expression changes after CRISPR perturbations, using >270,000 perturbations to detect CREs for multiple genes.

The paper introduces CATCH, a method for designing compact and scalable probe sets to enhance metagenomic sequencing sensitivity, demonstrating improved viral genome recovery and diversity preservation.

This study sequenced 110 Zika virus genomes from 10 countries, revealing rapid expansion in Brazil, multiple introductions into other regions, and undetected circulation before confirmed cases.

This study compares monoclonal and polyclonal antibodies for ChIP-seq of histone modifications, finding monoclonals perform similarly in most cases but show differences for H3K27ac.