Author

Juan Ignacio Jiménez‐Loygorri

Spanish National Cancer Research CentreORCID 0000-0002-3065-9952Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Developmental Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:mechanistic / dynamical model· 1 Organism:mouse· 1

Frequent Co-Authors

Alba C. ArconesiD· 2 shared Guadalupe SabioiD· 2 shared Luis Leiva‐VegaiD· 2 shared María Elena RodrígueziD· 2 shared Marta LeoniD· 2 shared Albana GattelliiD· 1 shared Alfonso MoraiD· 1 shared Ángel R. NebredaiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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2 shared papersMolecular Biology

Alba C. ArconesORCID

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Author profile →

3 papers

Recent·Most cited

Adipocyte MKK3 Increases in Human Obesity protecting against Insulin Resistance by p38-beta activation

Edgar Bernardo, Nuria Matesanz, Jorge Luis Torres, Alba C. Arcones, Juan Ignacio Jiménez‐Loygorri, Alfonso Mora, Leticia Herrera‐Melle, Luis Leiva‐Vega, María Elena Rodríguez, Lourdes Hernández‐Cosido, Marta Leon, Paula Yong González, Teresa Durán, Tamara Parracho, Francisca Mulero, , Guadalupe Sabio

The paper investigates the role of MKK3 in adipose tissue during obesity, finding that its activation protects against insulin resistance by enhancing p38-beta signaling.

Advanced Science · Oct 28, 2026Peer-reviewedMolecular Biology

TUMOR-PRE-ADIPOCYTE CROSSTALK SUSTAINS BREAST CANCER GROWTH VIA RET SIGNALLING

Sabrina A. Vallone, Ángela Lara Montero, Alba C. Arcones, Irene Ruiz-Garrido, Marcos D. Palavecino, M Montani, Juan Ignacio Jiménez‐Loygorri, Ivana Nikolić, Martín E. García Solá, Luis Leiva‐Vega, Marta Leon, Gladys N. Hermida, María Elena Rodríguez, Paula Aguirre, Daniela Maltagliatti, , Albana Gattelli

This study shows breast tumors sustain growth by manipulating adipocytes into pre-adipocytes through RET signaling, which promotes tumor progression.

bioRxiv · May 8, 2026 · PreprintCancer Biology

The developing retina undergoes mitochondrial remodeling via PINK1/PRKN-dependent mitophagy

Juan Zapata‐Muñoz, Juan Ignacio Jiménez‐Loygorri, Michael Stumpe, Beatriz Villarejo‐Zori, Sandra Alonso‐Gil, Petra Terešak, Benan John Mathai, Ian G. Ganley, Anne Simonsen, Jörn Dengjel, Patricia Boya

The paper identifies two mitophagy peaks during retinal development, one PINK1-independent and one PINK1-dependent, linked to oxidative stress and RGC differentiation.

Journal of Molecular Biology · Jun 3, 2025Peer-reviewedDevelopmental Biology