The paper investigates the role of MKK3 in adipose tissue during obesity, finding that its activation protects against insulin resistance by enhancing p38-beta signaling.

Advanced Science · Oct 28, 2026Peer-reviewedMolecular Biology

Integrated molecular and functional profiling identifies E0771 as a basal-like triple-negative breast cancer model

Diana Baxter, Jordi Elvira-Lopez, Maria del Mar Isern, Jackeline Vanessa Huaca, María Teresa Blasco, Roger R. Gomis, Begoña Cánovas, Ángel R. Nebreda

This study characterizes the E0771 cell line as a triple-negative breast cancer model through molecular and functional analysis, confirming its hormone resistance and basal-like identity.

bioRxiv · Jul 15, 2026 · PreprintCancer Biology

The PIN1-p38-CtIP signaling axis protects stalled replication forks from deleterious degradation

Francesca Vivalda, Marco Gatti, Letizia Manfredi, Hülya Dogan, Antônio Porro, Giulio Collotta, Ilaria Ceppi, Christine von Aesch, Vanessa van Ackeren, Sebastian Wild, Martin Steger, Begoña Cánovas, Monica Cubillos‐Rojas, Antoni Riéra, Petr Ćejka, , Alessandro A. Sartori

This study identifies the PIN1-p38-CtIP signaling pathway as essential for protecting stalled replication forks from degradation, independent of its role in homologous recombination.

Nucleic Acids Research · Mar 31, 2025Peer-reviewedMolecular Biology

A dynamic equilibrium between TTP and CPEB4 controls mRNA stability and inflammation resolution

Clara Suñer, Annarita Sibilio, Judit Martín, Chiara Lara Castellazzi, Óscar Reina, Iván Dotú, Adrià Caballé, Elisa I. Rivas, Vittorio Calderone, Juana Díez, Ángel R. Nebreda, Raúl Méndez

The paper shows that CPEB4 and TTP regulate mRNA stability during inflammation resolution through competing polyadenylation and deadenylation, shaping the inflammatory response.

eLife · Apr 20, 2022Peer-reviewedMolecular Biology