Margaret Wrensch

Multi-Omics Study of Ancestry in Adults with Intracranial Cancers Glioma (MOSAIC)

This study analyzes a diverse glioma cohort to show ancestry influences on survival, somatic alterations, and mutational processes in diffuse gliomas.

Genetic predisposition to altered blood cell homeostasis is associated with glioma risk and survival

This study identifies genetic associations between blood cell traits and glioma risk and survival, highlighting immune-mediated mechanisms and subtype-specific effects.

Genome-wide Polygenic Risk Scores Predict Risk of Glioma and Molecular Subtypes

This study develops a novel polygenic risk score (PRS-CS) for glioma that outperforms existing methods, improving risk prediction and subtype classification using genome-wide association study data.

Assessment of Polygenic Architecture and Risk Prediction based on Common Variants Across Fourteen Cancers

This study assesses polygenicity and risk prediction using common variants across 14 cancers, finding varying numbers of susceptibility variants and risk score effectiveness.

Cross-cancer pleiotropic associations with lung cancer risk in African Americans

This study identifies three novel genomic regions associated with lung cancer risk in African Americans, showing pleiotropic effects across multiple cancers.